Ketamine Hydrochloride Injection, USP, for intravenous or intramuscular use, consists of ketamine, a nonbarbiturate general anesthetic. Ketamine hydrochloride, USP is often a white crystalline powder and has a molecular formula of C13H16ClNO•HCl and also a molecular fat of 274.
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Just like other common anesthetic brokers, the individual reaction to ketamine hydrochloride is to some degree diverse depending on the dose, route of administration, and age of affected individual, to ensure that dosage suggestion can not be absolutely preset. The drug must be titrated versus the patient's prerequisites.
Increments of 1-50 percent to the full induction dose might be recurring as wanted for upkeep of anesthesia. Nevertheless, it ought to be famous that purposeless and tonic-clonic actions of extremities may possibly take place over the study course of anesthesia.
Male and woman rats, when supplied five times the common human intravenous dose of ketamine hydrochloride for three consecutive days about one 7 days before mating, had a reproductive performance comparable to that of saline-injected controls. When supplied to Expecting rats and rabbits intramuscularly at twice the standard human intramuscular dose during the respective durations of organogenesis, the litter attributes ended up equivalent to 3-FMC These of saline-injected controls.
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Ketamine Hydrochloride Injection is contraindicated in people for whom an important elevation of hypertension would represent a serious hazard [see Warnings and Safety measures (5.
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Laryngospasms along with other varieties of airway obstruction have occurred for the duration of ketamine hydrochloride anesthesia.
Amplified intracranial force may well come about; even so, There is certainly proof that ketamine might be safely and securely and efficiently Employed in individuals with head accidents or danger of intracranial hypertension.
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